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In another aspect, the invention provides a method for the prophylaxis or treatment of or alleviating or reducing the incidence of cancer in a patient suffering from or suspected of suffering from cancer; which method comprises i subjecting a patient to a diagnostic test to determine whether the patient possesses the Ile31 variant of the Aurora A gene; and ii where the patient does possess the said variant, thereafter administering to the patient a compound of formula I as defined herein having Aurora kinase inhibiting activity, wherein the patient is undergoing treatment with an ancillary compound cialis generic online Kimberly cYrfItQiAlSsAji 6 20 2022